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Dr. Joon Song Provides a Brief Overview of Fibrinoid Necrosis


Fibrinoid necrosis is a form irreversible and uncontrolled cellular death that occurs when antigen-antibody complexes are deposited in the walls of blood vessels, resulting in the formation of fibrous tissue. Associated with extensive vascular damage, fibrinoid necrosis can lead to long-term health complications if not properly treated.

Dr. Joon Song — is a highly specialized gynecologist and obstetrician, with over 30 years of experience in the medical field. Having established his own practice in New York, the Robotic Gynecology & Women’s Health Center, he works diligently to ensure his patients receive top quality care. He takes the time to outline what individuals need to know about fibrinoid necrosis.

Understanding Fibrinoid Necrosis

Fibrinoid necrosis is the result of a hypersensitive immune system, specifically called type III hypersensitivity, where antigen-antibody complexes (complexes of proteins and disease-causing bacteria or viruses that initiate immune-system response) are not cleared by the immune system, resulting in inflammation and disease.

The inflammation is a result of these complexes nestling into the blood vessels walls, along with fibrin — a fibrous tissue that created during the process of blood clotting), which then creates a type of “mesh,” stopping the flow of blood through arteries and vessels. This creates the conditions for dangerously high blood pressure that, if left untreated, could lead to death.

Health Conditions Related to Necrosis

Fibrinoid necrosis is present in several different health conditions, including pre-eclampsia (high blood pressure during pregnancy), malignant hypertension (a medical emergency that causes organ damage), vasculitis (inflammation of the blood vessels), and even organ-transplant rejection.

When the cells of the blood vessels are destroyed, there may be bleeding throughout the body, which can manifest in a myriad of symptoms.

Symptoms of This Condition Include (but are not limited to):

  • Epistaxis (nosebleeds)
  • Gum bleeding
  • Blood in urine
  • Blood in stool
  • Muscle bruises
  • Hemorrhage of the organs
  • Gastrointestinal haemorrhage
  • Rupture of the spleen
  • Traumatic and surgical bleeding


There is no way to properly diagnose fibrinoid necrosis without a microscope as there is no general analysis that can be done. Under a microscope, tissues will appear pink and vessel walls ill-defined. The pink is a combination of the necrotic tissue, fibrin and immune complexes.

Treatment Options

There is no specific treatment for fibrinoid necrosis on its own. Instead, the approach involves treating the symptoms of the illness that caused it. If the fibrinoid necrosis was caused by very high blood pressure, for instance, medication to lower blood pressure will be prescribed such as diuretics (to decrease blood volume), beta-blockers (to lower the heart rate by blocking adrenaline) and ACE inhibitors (to dilate blood vessels and lower blood pressure).

Each cause will have specialized medications and protocols to address and treat it. Our office can help you determine the root cause, and propose individual treatment based on your symptoms and needs. Additionally, it is imperative to seek proper medical care to avoid any further help complications.

For further information on Dr. Joon Song and his practice please visit https://www.joonsongmd.com/

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